简述植物内生真菌的概念、特点以及与宿主的重要关系,综述全球范围内过去20年该领域的研究进展,强调“基于植物内生真菌开发新药逐渐成为热点”。1内生真菌活性成分从药用植物中分离得到的内生菌,经过人工培养,能够在培养物中产生某些活性成分,大多为抗肿瘤活性成分,其次为抗炎 The concept, characteristics and important relationship with the host of the endophytic fungi in plants are briefly described. The research progress in this field in the past 20 years is reviewed globally, and it is emphasized that “the development of new drugs based on endophytic fungi has gradually become a hot topic.” 1 Endophytic fungi Active ingredients isolated from medicinal plants Endogenous bacteria, after artificial cultivation, can produce some active ingredients in culture, mostly anti-tumor active ingredients, followed by anti-inflammatory