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以往的胃癌免疫形态学研究认为瘤组织中淋巴样细胞浸润程度及癌周淋巴结某些形态变化同预后及肿瘤细胞的生物学性质有关。但是这些都仅限于组织水平的观察,即采用病理组织学方法,其观察指标的分类分级均缺乏客观的统一标准。所以目前对于进行期胃癌宿主免疫反应方式(即细胞免疫和体液免疫)及其同预后和肿瘤生物学性质之间关系尚存在不同看法。本项研究从细胞水平的定量观察,对上述问题进行了初步探讨。
The previous immunohistochemical study of gastric cancer suggested that the degree of lymphoid cell infiltration and certain morphological changes of the lymph nodes around the tumor are related to the prognosis and the biological properties of the tumor cells. However, these are limited to the observation of the level of organization, that is, the use of histopathological methods, the classification of the observation index and the lack of objective uniform standards. Therefore, there are still different opinions on the relationship between the host immune response in advanced gastric cancer (ie, cellular immunity and humoral immunity) and its relationship with prognosis and tumor biological properties. In this study, quantitative observations at the cellular level were conducted to explore the above issues.