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<正> Lead (Pb) inhibited the activities of Na~+-K~+ ATPase (IC_(50)=2.0×10~(-6) M), K~+-Para-Nitrophenyl phosphatase (PNPPase) (IC_(50)=3.5×10(-6) M) and [~3H]-ouabain binding (IC_(50)= 4.0×10~(-5) M) in rat brain P2 fraction. A variab