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目的评价抗环瓜氨酸肽抗体(CCP)检测对类风湿关节炎(RA)的诊断价值。方法收集95例RA、80例非RA的其它风湿病患者以及40例健康人血清标本。采用ELISA方法检测抗CCP抗体。结果抗CCP抗体在RA组阳性率69.5%,非RA组的其它风湿病组阳性率2.5%,健康对照组阳性率0%,抗CCP抗体对RA的敏感度为69.5%,特异度为97.5%,阳性预测值为97.1%,阴性预测值为72.9%。RA组抗CCP抗体阳性平均浓度显著高于非RA的其它风湿病组和健康对照组(P<0.05)。结论抗CCP抗体对诊断RA的特异性极高,对RA和早期RA的诊断具有重要意义。
Objective To evaluate the diagnostic value of anti-cyclic citrullinated peptide antibody (CCP) for rheumatoid arthritis (RA). Methods Serum samples from 95 patients with RA, 80 patients with other rheumatic diseases other than RA and 40 healthy people were collected. Anti-CCP antibody was detected by ELISA. Results The positive rate of anti-CCP antibody in RA group was 69.5%. The positive rate of anti-CCP antibody in non-RA group was 2.5% and that in healthy control group was 0%. The anti-CCP antibody had a sensitivity of 69.5% and a specificity of 97.5% , The positive predictive value was 97.1%, the negative predictive value was 72.9%. The average positive concentration of anti-CCP antibody in RA group was significantly higher than that in other rheumatic disease group and healthy control group without RA (P <0.05). Conclusion The anti-CCP antibody is highly specific for the diagnosis of RA and is of great significance for the diagnosis of RA and early RA.