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自从1922年首次制成人用的胰岛素以来,生产的总原则直到现在没有多大的改变。至1972年为止,普通出售的各类胰岛素均来自牛或猪的胰腺浸出液,通过重结晶而纯化。长效制剂以重结晶胰岛素和鱼精蛋白(鱼精蛋白胰岛素)、锌与鱼精蛋白(鱼精蛋白锌胰岛素)或与锌(锌胰岛素)结合而制成。多数对胰岛素产生依赖性的糖尿病患者对各种动物来源的胰岛素均可产生胰岛素抗体反
The general principle of production has not changed much so far since the first human insulin was made in 1922. Until 1972, all kinds of insulin normally sold were derived from pancreatic extracts of cattle or pigs and purified by recrystallization. Long-acting formulations are made by recrystallizing insulin and protamine (protamine insulin), zinc in combination with protamine (protamine zinc insulin) or with zinc (zinc insulin). Most insulin-dependent diabetic patients can produce insulin antibody against various animal-derived insulin