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目的探讨研究早期药物干预对急性心肌梗死后抑郁症状的改善及心功能恢复的效果。方法选择2013年4月~2014年8月我院确诊为急性心肌梗死合并抑郁症状的患者84例,采取完全随机原则将患者分为干预组和对照组。对照组采用常规心肌梗死治疗,干预组在常规治疗基础上加用氟西汀(百忧解)20mg,1次/日。连续用药1个月后观测两组患者抑郁症状改善及心功能恢复的情况。结果干预组患者汉密斯抑郁量表(HAMD)评分以及心功能情况(心源性死亡、心力衰竭、心肌再梗死、梗死后心绞痛)明显优于对照组。结论早期应用抗抑郁药物干预可显著改善患者急性心肌梗死后的抑郁症状以及心功能的恢复情况。
Objective To investigate the effect of early drug intervention on the improvement of depression and recovery of cardiac function after acute myocardial infarction. Methods From April 2013 to August 2014, 84 patients with acute myocardial infarction complicated with depressive symptoms in our hospital were selected. Patients were divided into intervention group and control group according to completely random principle. The control group was treated with conventional myocardial infarction. The intervention group received fluoxetine (Prozac) 20 mg once daily on the basis of routine treatment. One month after continuous medication, depression symptoms and cardiac function recovery were observed in two groups. Results The HAMD score and cardiac function (heart-related death, heart failure, myocardial infarction and post-infarction angina) in the intervention group were significantly better than those in the control group. Conclusions Early use of antidepressant drugs can significantly improve the symptoms of depression and the recovery of cardiac function in patients with acute myocardial infarction.