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AIM:Both observational and experimental studies haveshown that higher selenium status reduces the risk of uppergastrointestinal cancers in selenium deficient populations.Recent cancer registry data have shown very different ratesof esophageal cancer(EC)and gastric cancer(GC)in fourProvinces of Iran,namely Ardabil,Mazandaran,Golestan,and Kerman.The aim of this study was to have apreliminary assessment of the hypothesis that high ratesof EC in Golestan and high rates of GC in Ardabil may bepartly attributable to selenium deficiency.METHODS:We measured serum selenium in 300 healthyadults from An:labil(n=100),Mazandaran(n=50),Golestan(n=100),and Kerman(n=50),using inductively coupledplasma,with dynamic reaction cell,mass spectrometry(ICP-DRC-MS)at the US Centers for Disease Control(Atlanta,Georgia).RESULTS:The median serum selenium concentrations werevery different in the four Provinces.The medians(IQR)forselenium in Ardabil,Mazandarn,Golestan,and Kermanwere 82(75-94),123(111-132),155(141-173),and 119(110-128)μg/L,respectively(P<0.001).The results of linearregression showed that the Province variable,by itself,explained 76% of the variance in log selenium(r~2=0.76).The proportion of the populations with a serum seleniummore than 90 μg/L(the concentration at which serumselenoproteins are saturated)was 100% in Golestan,Kerman,and Mazandaran but only 29% in Ardabil.CONCLUSION:Our findings suggest that selenium defidencyis not a major contributor to the high incidence of EC seenin northeastern Iran,but it may play a role in the highincidence of GC in Ardabil Province.Nouarie M,Pourshams A,Kamangar F,Sotoudeh M,DerakhshanMH,Akbari MR,Fakheri H,Zahedi MJ,Caldwell K,Abner CC,Taylor PR,Malekzadeh R,Dawsey SM.Ecologic study of serum
AIM: Both observational and experimental studies have show that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations. Central cancer registry data have shown very different rates of esophageal cancer (EC) and gastric cancer (GC) in four Provvies of Iran, namely Ardabil , Mazandaran, Golestan, and Kerman. The aim of this study was to have a preliminary assessment of the hypothesis that high rates of EC in Golestan and high rates of GC in Ardabil may bepartly attributable to selenium deficiency. METHODS: We measured serum selenium in 300 healthyadults from An: labil (n = 100), Mazandaran (n = 50), Golestan (n = 100), and Kerman (n = 50) using inductively coupled plasm with dynamic reaction cell, mass spectrometry (ICP-DRC- MS) at the US Centers for Disease Control (Atlanta, Georgia) .RESULTS: The median serum selenium concentrations were very different in the four Provinces.The medians (IQR) forselenium in Ardabil, Mazandarn, Golestan, and Kermanwere 82 (75-94), 123 (111-132), 155 (141- The results of linear regression showed that the province variable, by itself, explained 76% of the variance in log selenium (r ~ 2 = 0.76), and 119 (110-128) μg / . The proportion of the populations with a serum seleniummore than 90 μg / L (the concentration at which the serumselenoproteins are saturated) was 100% in Golestan, Kerman, and Mazandaran but only only 29% in Ardabil. CONCLUSION: Our findings suggest that selenium defidency not a major contributor to the high incidence of EC seen in northeastern Iran, but it may play a role in the highincidence of GC in Ardabil Province. Nouarie M, Pourshams A, Kamangar F, Sotoudeh M, Derakhshan MH, Akbari MR, Fakheri H, Zahedi MJ , Caldwell K, Abner CC, Taylor PR, Malekzadeh R, Dawsey SM. Ecologic study of serum