【摘 要】
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To understand the epidemiological and clinical features of the symptomatic and asymptomatic pediatric cases of COVID-19,we carried out a prospective study in Sh
【机 构】
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Department of Infectious Diseases, Children’s Hospital of Fudan University, Shanghai 201102, China;D
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To understand the epidemiological and clinical features of the symptomatic and asymptomatic pediatric cases of COVID-19,we carried out a prospective study in Shanghai during the period of January 19 to April 30,2020.A total of 49 children(mean age 11.5 ± 5.12 years)confirmed with SARS-CoV-2 infection were enrolled in the study,including 11(22.4％)domestic cases and 38(77.6％)imported cases.Nine(81.8％)local cases and 12(31.6％)imported cases had a definitive epidemiological exposure.Twenty-eight(57.1％)were symptomatic and 21(42.9％)were asymptomatic.Neither asymp-tomatic nor symptomatic cases progressed to severe diseases.The mean duration of viral shedding for SARS-CoV-2 in upper respiratory tract was 14.1 ± 6.4 days in asymptomatic cases and 14.8 ± 8.4 days in symptomatic cases(P ＞ 0.05).Forty-five(91.8％)cases had viral RNA detected in stool.The mean duration of viral shedding in stool was 28.1 ± 13.3 days in asymptomatic cases and 30.8 ± 18.6 days in symptomatic participants(P ＞ 0.05).Children ＜ 7 years shed viral RNA in stool for a longer duration than school-aged children(P ＜ 0.05).Forty-three(87.8％)cases had seropositivity for antibodies against SARS-CoV-2 within 1-3 weeks after confirmation with infection.In conclusion,asymptomatic SARS-CoV-2 infection may be common in children in the community during the COVID-19 pandemic wave.Asymptomatic cases shed viral RNA in a similar pattern as symptomatic cases do.It is of particular concern that asymptomatic individuals are potentially seed transmission of SARS-CoV-2 and pose a challenge to disease control.
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