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目的 :研究慢性肾衰竭患者合并冠心病稳定型心绞痛使用曲美他嗪治疗的临床疗效。方法 :选取慢性肾衰竭合并冠心病稳定型心绞痛患者 6 5例 ,分为曲美他嗪组与硝酸异山梨酯组 ,治疗 4周。观察心绞痛发作次数、心率、血压、心电图、动态心电图变化。结果 :曲美他嗪组与硝酸异山梨酯组治疗后明显减少心绞痛发作次数 ,临床症状改善 ,运动耐力增加 ,ECG运动试验 ,ST段下降 1mm时间延长 ,而两组对比差异无显著性。结论 :曲美他嗪与硝酸异山梨酯治疗慢性肾衰竭合并冠心病稳定型心绞痛有相似疗效
Objective: To study the clinical efficacy of trimetazidine in patients with chronic renal failure and stable angina pectoris. Methods: Sixty-five patients with chronic renal failure and stable angina pectoris were enrolled and divided into trimetazidine group and isosorbide dinitrate group for 4 weeks. Observed the number of angina attacks, heart rate, blood pressure, ECG, Holter changes. Results: Trimetazidine group and isosorbide dinitrate group significantly reduced the number of angina attacks, clinical symptoms, increased exercise tolerance, ECG exercise test, ST segment decreased 1mm time, but no significant difference between the two groups. CONCLUSIONS: Trimetazidine and isosorbide dinitrate have similar efficacy in the treatment of patients with chronic renal failure and stable angina pectoris