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目的建立发病过程类似人类代谢综合症(MS)的动物模型,观察过氧化物酶体增殖物激活受体γ(PPARγ)激动剂罗格列酮对该模型的药效作用。方法Wistar大鼠用高果糖高脂饲料喂养诱导产生MS的各项体征,给予药物治疗4周,用尾部测量法测定收缩期血压,用口服葡萄糖耐量实验(OGTT)与胰岛素糖耐量实验(ITT)评价胰岛素敏感性。结果高糖高脂饮食后2个月,大鼠产生高胰岛素血症,胰岛素抵抗和高脂血症,体重、血压都明显升高,空腹血糖轻度升高。药物治疗后能够明显降低高胰岛素血症,改善胰岛素抵抗和高脂血症。结论高果糖高脂饲料喂养,可以建立较好的模拟人类MS的动物模型,罗格列酮能够对MS的各项指征起到较好的改善作用。
OBJECTIVE: To establish an animal model of human metabolic syndrome (MS), and to observe the pharmacodynamic effects of rosiglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, on this model. Methods Wistar rats were induced with high-fructose and high-fat diet to induce various signs of MS. After 4 weeks of treatment, the systolic blood pressure was measured by tail measurement. OGTT, ITT, Evaluate insulin sensitivity. Results High glucose and high fat diet for 2 months, rats produce hyperinsulinemia, insulin resistance and hyperlipidemia, body weight, blood pressure were significantly increased, mild fasting blood glucose increased. After drug treatment can significantly reduce hyperinsulinemia, improve insulin resistance and hyperlipidemia. Conclusion High fructose and high-fat diet can establish a good animal model of human MS and rosiglitazone can improve the indications of MS.