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目的 探讨治疗相关性白血病的治疗方法。方法 分析我所 1985～ 2 0 0 3年收治的 4 8例治疗相关性白血病。结果 临床各型占同期各类白血病的 0 6 % ,占AML的 7%。 4 8例中放疗所致的相关性白血病全部为CML ,化疗所致的相关性白血病全部为AML。化疗主要的药物为鬼臼类 ,烷化剂和蒽环类药物。但对Ph阳性的CML应用STI5 71,有 2例病人获长期生存。APL应用三氧化二砷 +ATRA双诱导治疗后全部获CR ,1例无病生存 7年。结论 治疗相关性白血病对治疗反应较差 ,CR率极低。
Objective To investigate the treatment of associated leukemia. Methods Forty-eight treatment-related leukemias treated in our hospital from 1985 to 2003 were analyzed. Results The clinical types accounted for 0 6% of all kinds of leukemia in the same period, accounting for 7% of AML. 48 cases of radiotherapy-induced leukemia all CML, chemotherapy-related leukemia all AML. The main drugs for chemotherapy are podophyllotoxins, alkylating agents and anthracyclines. However, STI5 71 was used for Ph-positive CML, and 2 patients had long-term survival. APL application of arsenic trioxide + ATRA double induction therapy were all CR, 1 case of disease-free survival of 7 years. Conclusion The treatment-related leukemia response to treatment is poor, CR rate is extremely low.