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环一磷腺苷(cAMP)是生物细胞内普遍存在的一种化学物质,有介导细胞外刺激因子,调节不同类型细胞多种物质代谢和生理功能的作用,如控制细胞生长、抑制细胞运动、增加粘附性、恢复转化细胞的形态和接触抑制等。我们报告过cAMP能抑制U_(14)移植瘤的生长,并引起U_(14)实体瘤细胞粗面内质网表面和胞质内游离的聚核糖体解体,说明cAMP能导致瘤细胞的蛋白合成减少。为了进一进研究cAMP对瘤细胞的作用及其机制,我们观察了cAMP对U_(14)腹水型瘤细胞核、聚核糖体及微管等超微结构的影响。
Cyclic adenosine monophosphate (cAMP) is a ubiquitous chemical substance in biological cells that mediates extracellular stimulating factors and regulates the metabolism and physiological functions of various types of cells, such as controlling cell growth and inhibiting cell motility. , increase adhesion, restore transformed cell morphology and contact inhibition. We have reported that cAMP can inhibit the growth of U_(14) xenografts and cause the disintegration of free ribosomes on the surface of rough endoplasmic reticulum and intracytoplasm of U_(14) solid tumor cells, indicating that cAMP can cause protein synthesis in tumor cells. cut back. In order to further study the effect of cAMP on tumor cells and its mechanism, we observed the effect of cAMP on the ultrastructure of U_(14) ascites tumor nuclei, polyribosomes, and microtubules.