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采用反相ＨＰＬＣ法测定人血清中氯唑沙宗浓度。线性范围０．２６±６２．５２μｇ，ｍｌ￣（－１），高、中、低３种浓度回收率分别为９７．０％±２．３％，９７．１％±３．５％，９３．８％±３．０％（ｎ＝５），日内、日间ＲＳＤ均＜４．８％。以本法测定８例．怒愿受试者氯唑沙宗血药浓度，并计算分析药代动力学参数，结果单剂量口服８００ｍｇ氯唑沙宗后，药时曲线呈一室模型。Ｔ＿（ｍａｘ）＝１．６３±０．４３ｈ，Ｃ＿（ｍａｘ）＝１９．７１±３．９０μｇ·ｍｌ￣（－１），ＡＵＣ＿（０～∞）＝８２．２０±１１．３１ｍｇ·ｈ·Ｌ￣（－１），Ｋａ＝０．９２±０．３８ｈ￣（－１），Ｋｅ＝０．５４±０．１１ｈ￣（－１），Ｔ＿（１／２）＝１．３１±０．２４ｈ，Ｖｄ＝１８．６３±３．１５Ｌ，Ｃｌ＝９．９２±１．５５Ｌ·ｈ￣（－１）。
The concentration of chlorzoxazone in human serum was determined by reverse phase HPLC. The linear range was 0.26 ± 62.52μg, ml ~ (-1). The recoveries of high, medium and low concentrations were 97.0% ± 2.3% and 97.1% ± 3.5%, respectively .8% ± 3.0% (n = 5). The intra-day and inter-day RSD were both <4.8%. Eight cases were measured by this method. Anxious to test the concentration of chlorzoxazone blood, and calculate the analysis of pharmacokinetic parameters, the results of a single oral dose of 800mg clozaprazide, the drug curve was a one-compartment model. T max = 1.63 ± 0.43 h, C max = 19.71 ± 3.90 μg · ml -1, AUC 0 ~ ∞ = 82.20 ± 11.31 mg · h · L ~ (-1), Ka = 0.92 ± 0.38h ~ (-1), Ke = 0.54 ± 0.11h ~ (-1), T ~ (1/2) = 1.31 ± 0. 24h, Vd = 18.63 ± 3.15L, Cl = 9.92 ± 1.55L · h ~ (-1).