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目的探讨宫颈液基薄层细胞学检查(TCT)联合DNA定量分析在桂西壮族妇女宫颈病变筛查中的价值。方法选取同时行TCT、细胞DNA定量分析和活组织病理学检查的430例资料进行分析。宫颈脱落细胞液基薄层制片,1张巴氏染色做TCT诊断,1张Feulgen染色,应用全自动细胞图像分析系统扫描诊断。结果以活检结果作为诊断的金标准,TCT、DNA定量分析和联合检测的检出率分别为64.2%、90.6%和96.2%。联合检测与单独DNA定量分析检出率比较,差异不显著(P>0.05),联合检测与单独TCT的检出率比较,TCT与DNA定量分析的检出率比较,差异均显著(P<0.01)。结论 DNA定量分析检出率高于TCT,二者联合应用并不能有效地提高宫颈病变的检出率。
Objective To investigate the value of cervical cytology-based thin-layer cytology (TCT) combined with DNA quantitative analysis in cervical screening of Guangxi Zhuang women. Methods The data of 430 patients who underwent simultaneous TCT, DNA quantitative analysis and biopsy were analyzed. Cervical exfoliated cells, liquid-based thin-layer film production, a Papn staining TCT diagnosis, a Feulgen staining, the application of automatic cell image analysis system scanning diagnosis. Results The biopsy results were taken as the gold standard for diagnosis. The detection rates of TCT, DNA quantification and combined detection were 64.2%, 90.6% and 96.2% respectively. The detection rate of the combined detection of DNA and TCT was not significantly different (P> 0.05). The detection rate of TCT and DNA was significantly higher than that of TCT alone (P <0.01) ). Conclusion The detection rate of DNA quantitative analysis is higher than that of TCT. The combination of the two can not effectively improve the detection rate of cervical lesions.