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目的:探讨影响肝门部胆管癌术后生存率的因素。方法:回顾性分析2001年1月至2011年12月在我科接受手术治疗后出院的90例肝门部胆管癌病人的临床资料,对可能影响生存率的17个因素进行单因素分析,并用COX回归模型进行多因素分析,采用Kaplan-Meier法统计生存率。结果:本研究病人的1、2、3年生存率分别为42.6%、30.0%、22.5%,中位生存时间为10个月。COX回归分析结果显示手术方式与淋巴结转移是影响肝门部胆管癌术后生存率的独立因素。结论:早期发现并进行根治性切除是改善肝门部胆管癌病人预后的关键因素,化疗能提高中、晚期肝门部胆管癌病人的生存率。
Objective: To explore the factors that influence the postoperative survival rate of hilar cholangiocarcinoma. Methods: The clinical data of 90 patients with hilar cholangiocarcinoma discharged from our department from January 2001 to December 2011 were retrospectively analyzed. Univariate analysis was performed on 17 factors that may affect the survival rate. COX regression model for multivariate analysis, using Kaplan-Meier survival rate statistics. Results The 1, 2, 3-year survival rates of patients in this study were 42.6%, 30.0% and 22.5%, respectively. The median survival time was 10 months. COX regression analysis showed that surgical methods and lymph node metastasis were independent factors affecting the postoperative survival rate of hilar cholangiocarcinoma. Conclusion: The early detection and radical resection is the key factor to improve the prognosis of patients with hilar cholangiocarcinoma. Chemotherapy can improve the survival rate of patients with hilar cholangiocarcinoma.