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目的:研究肠炎宁颗粒的抗炎止泻作用。方法:用蓖麻油致小鼠腹泻模型,以腹泻指数、稀便率为指标观察其止泻作用;用二甲苯致小鼠耳肿胀观察其抗炎作用;用体外抑菌试验研究其抑菌抗菌作用。结果:肠炎宁颗粒剂可减少蓖麻油致腹泻小鼠腹泻指数和稀便率;能抑制二甲苯引起的耳肿;体外抑菌试验佐证了其对大肠杆菌和痢疾杆菌有一定的抑制作用。结论:肠炎宁颗粒剂具有抗炎、止泻作用。
Objective: To study the anti-inflammatory and antidiarrheal effects of Changyanning Granules. Methods: The model of mice diarrhea induced by castor oil was used to observe the antidiarrheal effect of diarrhea index and sparse stool rate; the ear swelling of mice was observed with xylene to observe its anti-inflammatory effect; the antibacterial effect was studied by antibacterial test in vitro. effect. RESULTS: Changyanning granules can reduce the diarrhea index and sparse stool rate of mice with diarrhea caused by castor oil, and can inhibit the ear swelling caused by xylene. The in vitro antibacterial test confirmed its inhibitory effect on Escherichia coli and Shigella. Conclusion: Changyanning granules have anti-inflammatory and anti-diarrhea effects.