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目的探讨海洋性贫血对尿毒症患者肾移植效果的影响。方法为46例合并海洋性贫血的尿毒症患者施行肾移植(海洋性贫血组),其中α海洋性贫血26例,β海洋性贫血20例,观察患者术后移植肾功能恢复延迟(DGF)和排斥反应的发生率以及贫血的纠正情况,对于移植肾功能恢复正常者,记录其肾功能恢复正常的时间,并测定血肌酐值。以同期施行的131例肾移植(均伴有程度不等的贫血,但非海洋性贫血)为对照。结果海洋性贫血组DGF的发生率为26.1%,对照组为23.7%,二者比较,差异无统计学意义。术后6个月,人、肾均存活,且未失访的患者,海洋性贫血组有39例,对照组有109例,6个月内,海洋性贫血组30.8%发生排斥反应,对照组32.1%发生排斥反应,两组比较,差异无统计学意义;海洋性贫血组的血肌酐值为(121±20)μmol/L,对照组为(128±33)μmol/L,两组比较,差异无统计学意义;海洋性贫血组79.5%的贫血得到纠正,对照组76.1%的贫血得到纠正,两组比较,差异无统计学意义。结论合并海洋性贫血的尿毒症患者可接受肾移植治疗,临床效果与不合并该病者相仿。
Objective To investigate the effect of marine anemia on renal transplantation in uremic patients. Methods Renal transplantation (marine anemia group) was performed in 46 cases of uremic patients with marine anemia, including 26 cases of α-thalassemia and 20 cases of β-thalassemia. The postoperative delayed graft recovery (DGF) and The incidence of rejection and the correction of anemia, for those with normal renal allograft function, recorded the normal time of renal function, and measured serum creatinine. 131 kidney transplants (all with varying degrees of anemia but not marine anemia) were performed as controls over the same period. Results The incidence of DGF was 26.1% in marine anemia group and 23.7% in control group. There was no significant difference between the two groups. Six months after surgery, both human and kidney survived. Among the patients who did not follow-up, there were 39 cases in marine anemia group and 109 cases in control group. Within 6 months, rejection occurred in 30.8% of marine anemia patients. In control group 32.1% had rejection. There was no significant difference between the two groups. Serum creatinine was (121 ± 20) μmol / L in marine anemia group and (128 ± 33) μmol / L in control group, There was no significant difference between the two groups. 79.5% anemia was corrected in marine anemia group and 76.1% anemia in control group was corrected. There was no significant difference between the two groups. Conclusions Patients with uremia complicated with anemia of the sea can be treated with kidney transplantation. The clinical effect is similar to those without the disease.