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目的探讨比较卵巢癌患者血清中卵泡抑素(FS)、人附睾分泌蛋白4(HE4)及糖链抗原125(CA125)的表达情况在卵巢癌诊断中的临床价值。方法根据手术后的病理结果将诊断为盆腔包块实施手术治疗的67例均为卵巢癌患者分为实验A组,36例均为盆腔良性包块患者分为实验B组,另外选取同一时期体检健康的女性40例为对照组,对3组受试者进行FS、HE4和CA125水平检测和分析。结果实验A组的FS(3.12±0.45)μg/L、HE4(377.51±47.38)pmol/L和CA125(83.78±3.92)U/ml的表达水平均高于实验B组和对照组,差异有统计学意义(P<0.05),实验B组与对照组比较差异无统计学意义(P>0.05);HE4(94.44%)的特异性高于FS(91.67%)和CA125(69.44%),CA125(79.10%)的敏感性高于FS(56.72%)和HE4(73.13%)。结论血清中FS、HE4和CA125在卵巢癌患者中呈现高表达,根据三者的敏感性和特异性择优选择检查项目,对卵巢癌的诊断具有重要价值。
Objective To investigate the clinical value of serum FSH, HE4 and CA125 in the diagnosis of ovarian cancer. Methods According to the postoperative pathological findings, 67 cases diagnosed as pelvic masses for surgical treatment were divided into experimental group A, 36 cases were treated with pelvic benign mass, divided into experimental group B. In addition, the same period of physical examination 40 healthy women as the control group, the three groups of subjects FS, HE4 and CA125 levels were detected and analyzed. Results The expression levels of FS (3.12 ± 0.45) μg / L, HE4 (377.51 ± 47.38) pmol / L and CA125 (83.78 ± 3.92) U / ml in experimental group A were significantly higher than those in experimental group B and control group The specificity of HE4 (94.44%) was higher than that of FS (91.67%) and CA125 (69.44%), and the level of CA125 (P0.05). There was no significant difference between the experimental group B and the control group 79.10%) were higher than FS (56.72%) and HE4 (73.13%). Conclusions Serum FS, HE4 and CA125 are highly expressed in ovarian cancer patients. According to the sensitivity and specificity of the three, they are important candidates for the diagnosis of ovarian cancer.