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目的 了解基质金属蛋白酶２（ Ｍ Ｍ Ｐ２） 及其作用底物Ⅳ型胶原（ Ｃｏｌ Ⅳ） 在慢性乙型肝炎患者组织中表达的变化。方法 应用免疫组织化学方法，对不同炎症活动程度的慢性乙型肝炎患者肝穿刺标本作 Ｍ Ｍ Ｐ２ 、 Ｃｏｌ Ⅳ的半定量和定位研究。结果 Ｍ Ｍ Ｐ２ 、 Ｃｏｌ Ⅳ在慢性乙型肝炎患者病变中的表达与炎症活动程度相关，炎症活动度高的病例其表达显著高于炎症活动度低者。结论 提示 Ｍ Ｍ Ｐ２ 在慢性肝炎患者的肝组织结构破坏和重建中起作用，参与肝纤维化的始动机制。
Objective To investigate the expression of matrix metalloproteinase-2 (M M P2) and its acting substrate type Ⅳ collagen (Col Ⅳ) in chronic hepatitis B patients. Methods Immunohistochemistry was used to study the semi-quantitative and localization of M M P2 and Col Ⅳ in liver biopsy specimens of chronic hepatitis B patients with different degrees of inflammatory activity. Results M M P 2, Col Ⅳ expression in patients with chronic hepatitis B and the extent of inflammatory activity related to the high inflammatory activity cases were significantly higher than those with low inflammatory activity. Conclusions M M P 2 plays a role in the destruction and reconstruction of liver tissue in patients with chronic hepatitis, and is involved in the initiation mechanism of liver fibrosis.