目的探讨石家庄市出生缺陷儿发病情况和可能的危险因素。方法统计出生缺陷儿情况,调查孕妇婚前检查、孕早期发热、孕早期居室新装修、孕早期长时间使用电脑(每周大于20小时)以及孕期穿防辐射服的情况,计算5年来出生缺陷儿的发生率。结果 5年来新生儿缺陷发生率20.80‰,其中2010年出缺陷发生率10.62‰,2011年13.56‰,2012年23.37‰,2013年25.36‰,2014年25.44‰;5年来平均婚检率26%,婚检率呈逐年下降趋势;孕妇孕早期发热者出生缺陷儿发生率高;孕妇孕早期居室新装修者出生缺陷儿发生率高;孕妇孕早期使用电脑时间每周大于20小时者出生缺陷儿发生率高;孕母孕期穿防辐射服者出生缺陷儿发生率高。结论石家庄市5年来出生缺陷逐年上升;孕产妇婚检率下降、孕早期感染、孕早期居室新装修、孕早期长时间使用电脑及孕期穿防辐射服可能是出生缺陷儿发病的危险因素。 Objective To investigate the incidence and possible risk factors of birth defects in Shijiazhuang. Methods The incidence of birth defects was investigated. Premarital examination of pregnant women, fever in the first trimester, new decoration in the first trimester, computer use for a long time in the first trimester (more than 20 hours per week), and radiation protection during pregnancy were used to calculate the incidence of neonatal birth defects The incidence of. Results The incidence of neonatal defects in the past five years was 20.80 ‰, of which the incidence of defective births was 10.62 ‰ in 2010, 13. 56 ‰ in 2011, 23.37 ‰ in 2012, 25.36 ‰ in 2013 and 25.44 ‰ in 2014. The average premarital examination rate was 26% in 5 years and premarital examination The incidence of pregnancy-induced fever in early pregnancy was high in children with birth defects. The incidence of birth defects in pregnant women with newly renovated rooms in early pregnancy was high. The incidence of birth defects in pregnant women who used computers more than 20 hours per week in early pregnancy was high ; Pregnant women wear radiation protectors during pregnancy neonates with a high incidence of birth defects. Conclusion The birth defects in Shijiazhuang City have been increasing year by year. The rate of premarital premarital examination, infection in early pregnancy, new decoration in early pregnancy, prolonged use of computer in early pregnancy, and radiation protection during pregnancy may be the risk factors for the birth defects.