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药物相互作用分为药效学或药动学相互作用.后者发生在药物的吸收、分布、排泄和代谢过程中.药物代谢可改变药物的理化性质,增加或降低其生物活性,而一种化合物的代谢可被另一种化合物抑制或诱导.本文综述诸抗癌药代谢时的相互影响.环磷酰胺环磷酰胺本身无活性,在肝混合功能氧化酶系的作用下被羟化成为4-羟环磷酰胺和醛-磷酰胺,这些代谢物是体内细胞毒物,可能代表活化的烷化部分——磷酰胺芥的转运型.给大鼠单剂量注射环磷酰胺后4天可引起剂量依赖性的肝NADPH-细胞色素P-450还原酶活性降低48%,微粒体混合功能氧化酶活
Drug interactions are divided into pharmacodynamic or pharmacokinetic interactions, which occur during the absorption, distribution, excretion and metabolism of drugs Drug metabolism can alter the physicochemical properties of drugs and increase or decrease their biological activity, The metabolism of a compound may be inhibited or induced by another compound.This article reviews the interactions between anticancer drugs when metabolized.Cyclophosphamide Cyclophosphamide itself is inactive and is hydroxylated to 4 under the action of a mixed liver function oxidase -cytophosphamide and aldehyde-phosphoramidites, which metabolites are cytotoxic in vivo that may represent the translocation of the activated alkylating moiety, phosphoramidite.After 4 days of single dose injection of cyclophosphamide in a rat, a dose Dependent liver NADPH-cytochrome P-450 reductase activity decreased by 48%, microsomal mixed-function oxidase activity