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本文采用人外周血淋巴细胞染色体畸变分析、尿致突变性和核仁RNA活性测定方法,对接触一系列新生产的细胞抑制药物的化学实验室工人于服用潜在抗突变剂抗坏血酸(AA)前及服用6个月后分别进行了遗传危险性的研究,以验证补充AA的预防效果。研究对象为38名接触新生产的细胞生长抑制药物和其它化学品的化学实验室工人;另18名非接触者为对照组,大部份为图书馆管理员和办事员。每天服用AA 1g,每周服5天,连续6个月,定期检测尿中AA的排泄。外周血淋巴细胞染色体畸变分析用Hun-
In this study, we used a method to detect chromosomal aberrations of human peripheral blood lymphocytes, urine mutagenicity and determination of nucleolar RNA activity. The chemical laboratory workers exposed to a series of newly produced cytostatic drugs before taking the potential anti-mutagenic agent ascorbic acid (AA) After six months of taking genetic risk studies were conducted to verify the preventive effect of AA supplementation. The study population consisted of 38 chemical lab workers exposed to newly-produced cytostatics and other chemicals. The other 18 non-contact controls were control groups, most of whom were librarians and clerks. Take AA 1g daily for 5 days a week for 6 consecutive months and regularly test for the excretion of AA in the urine. Chromosome aberration analysis of peripheral blood lymphocytes with Hun-