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近年来在非汞利尿剂的研究工作中有很大的进展,特别是自1950年發現醋氮酰胺(Diamox)后,由于这类抑制碳酸酐酶的药物有許多优点,如作用仅仅在单一酶系統,口服就有明显的利尿作用,而且比普通常用的嘌呤类利尿药以及汞制剂药效还要强,同时通过对这类药物的研究,进一步了解到利尿与盐代謝的关系,和电解质在机体平衡中的重要性。现在临床及病理生理和药理学家们正沿着这条路线在继续寻找新的利尿及降压药。继醋氮酰胺發現后,Novello及Sprague(1957)合成了一个杂环的磺酰胺化合物,后經动物和临床試驗証明,这种化合物具有明显的利尿作用。此药的化学
In recent years, there has been great progress in the research of non-mercury diuretics, especially since the discovery of Diamox in 1950, because of the many advantages of such drugs that inhibit carbonic anhydrase, such as the role of only a single enzyme. System, there is obvious diuretic effect of oral administration, and even more common than commonly used purine diuretics and mercury formulations efficacy, and through the study of such drugs, to further understand the relationship between diuresis and salt metabolism, and electrolytes in the body The importance of balance. Now clinical and pathophysiological and pharmacologists are continuing to search for new diuretic and antihypertensive drugs along this route. Following the discovery of acetamide, Novello and Sprague (1957) synthesized a heterocyclic sulfonamide compound, which was later confirmed by animal and clinical trials to demonstrate a significant diuretic effect. The chemistry of this drug