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二价咪唑铜配合物可以在电极表面发生氧化还原反应 ,该过程对应于单电子准可逆过程 .荧光光谱电化学结果表明 ,还原产物一价咪唑铜配合物可以被空气中的 O2 氧化为二价 .在中性的 Tris-HCl缓冲溶液中 ,配合物与 DNA之间存在弱相互作用 ,其键合常数仅为 2 .7× 1 0 2 L/mol.荧光光谱及电化学结果表明为嵌入式作用 .据此建立了一种电化学诱导咪唑铜配合物对 DNA断裂的新方法 ,并采用差示扫描量热 (DSC)法检验了断裂结果
The bivalent imidazole copper complex can undergo redox reaction on the surface of the electrode, which corresponds to the one-electron quasi-reversible process.Fluorescence spectroscopy shows that the monovalent imidazole copper complex can be oxidized by O2 in air to divalent In the neutral Tris-HCl buffer solution, there is a weak interaction between the complex and the DNA, the bond constant is only 2.7 × 102 L / mol.Fluorescence spectroscopy and electrochemical results showed that the embedded A new method of electrochemically induced DNA cleavage of imidazole copper complexes was established and the results of the cleavage were examined by differential scanning calorimetry (DSC)