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目的:探讨妊娠期高血压疾病患者血清甲胎蛋白(AFP)水平对母体及妊娠结局的影响。方法:采用放射免疫法测定118例妊娠中期妊娠期高血压疾病患者血清甲胎蛋白值,根据其AFP值分为观察组(≥250μg/L)54例和对照组(<250μg/L)64例,选取同期正常妊娠孕妇160例测定其血清AFP水平。所有孕妇均随访至分娩,分析妊娠期高血压疾病患者血清AFP水平对妊娠结局的影响。结果:妊娠期高血压疾病组血清AFP水平高于正常妊娠组,其中重度子痫前期组血清AFP水平明显高于正常妊娠组、妊娠期高血压组及轻度子痫前期组,而妊娠期高血压组及轻度子痫前期组与正常妊娠组比较无明显差异。孕妇尿蛋白、肾功能、眼底变化与其血清AFP水平有关。结论:孕妇血清AFP水平异常升高影响妊娠结局,对母体本身亦有一定影响。AFP值测定是一种无创性、操作简单、费用低廉的产前检查手段,妊娠中期孕妇血清AFP监测可做为妊娠期高血压疾病产检预测的一项有效尝试,值得临床进一步研究。
Objective: To investigate the effect of serum alpha-fetoprotein (AFP) level on maternal and pregnancy outcomes in patients with hypertensive disorder during pregnancy. Methods: The serum alpha-fetoprotein values of 118 pregnant women with gestational hypertension during pregnancy were determined by radioimmunoassay. According to their AFP values, 54 cases of observation group (≥ 250μg / L) and 64 cases of control group (<250μg / L) , Select the normal pregnant women of the same period 160 cases of serum AFP levels. All pregnant women were followed up to delivery, analysis of serum levels of AFP in patients with gestational hypertension disease on pregnancy outcomes. Results: Serum AFP level in gestational hypertension group was higher than that in normal pregnancy group. Serum AFP level in severe preeclampsia group was significantly higher than that in normal pregnancy group, gestational hypertension group and mild preeclampsia group, Blood pressure group and mild preeclampsia group compared with normal pregnancy group no significant difference. Pregnant women urinary protein, renal function, fundus changes and serum AFP levels. Conclusion: The abnormal increase of serum AFP level in pregnant women affects the outcome of pregnancy, and also affects the mother itself. AFP value determination is a noninvasive, simple and inexpensive prenatal examination. Serum AFP monitoring of pregnant women in the second trimester can be used as an effective try for pregnancy test for hypertensive disorders of pregnancy. It is worth further clinical study.