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目的:观察三七对三苯氧胺治疗瘀血证乳腺癌患者相关肝损伤的影响。方法:采用随机对照研究方法,将60例患者随机分为2组各30例,对照组予三苯氧胺治疗,治疗组在对照组治疗的基础上加用三七片治疗,共治疗12月,每3月评价脂肪肝程度及监测血谷草转氨酶(AST)及谷丙转氨酶(ALT)。结果:随着三苯氧胺治疗时间的延长,脂肪肝发生例数、脂肪肝分值、AST、ALT不断升高,对照组升高趋势更加明显。治疗后治疗组脂肪肝发生例数、脂肪肝分值、AST、ALT均显著低于对照组。结论:三七与三苯氧胺联合应用于瘀血证乳腺癌治疗,能够有效地保护肝功能,降低脂肪肝发生的机会。
Objective: To observe the effect of Panax notoginseng on the liver injury associated with tamoxifen in treating patients with stasis syndrome of breast cancer. Methods: A randomized controlled study, 60 patients were randomly divided into two groups of 30 cases, the control group was treated with tamoxifen, the treatment group in the control group on the basis of plus three seven tablets treatment, a total of 12 months treatment, every 3 Month evaluation of fatty liver and monitoring of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Results: With the prolongation of tamoxifen treatment time, the number of fatty liver, fatty liver score, AST, ALT increased continuously and the increase trend of control group became more obvious. After treatment, the number of cases of fatty liver, fatty liver score, AST and ALT in the treatment group were significantly lower than those in the control group. Conclusion: Panax notoginseng combined with tamoxifen can be used in the treatment of breast cancer with stasis syndrome, which can effectively protect liver function and reduce the chance of fatty liver.