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目的乳腺癌患者应用保乳手术及乳房再造术的远期临床效果及生活质量调查分析。方法 2001年1月—2005年6月收治的乳腺癌189例依据手术方式分为采取保留皮肤及乳头乳晕的皮下乳腺癌改良根治术加一期背阔肌肌皮瓣转移再造乳房术(乳房再造术组)99例,保留皮肤及乳头乳晕的皮下乳腺癌改良根治术(保乳手术组)90例,进行随访5年,观察两组病例远期临床效果、生活质量。结果两组远期临床效果观察,生存率、局部复发率、远处转移率,统计并进行比较无统计学意义(P>0.05)。两组病例在心理功能、身体形象、性功能上有统计学意义(P<0.05)。结论乳腺癌患者应用保乳手术及乳房再造术的远期临床效果无明显差异,但对患者的部分生活质量心理功能、身体形象、性功能有着影响。
Objective To investigate the long-term clinical effect and quality of life of breast conserving surgery and breast reconstruction surgery in patients with breast cancer. Methods One hundred and ninety-nine cases of breast cancer admitted from January 2001 to June 2005 were divided into three groups according to the surgical procedure: modified radical mastectomy with subcutaneous breast cancer with preserved skin and nipple areola; (N = 99). Ninety patients undergoing modified radical mastectomy (breast conserving surgery group) with preserved skin and nipple areola were followed up for 5 years. The long-term clinical effect and quality of life of the two groups were observed. Results The long-term clinical effects, survival rate, local recurrence rate, distant metastasis rate, statistics and comparison between the two groups were not statistically significant (P> 0.05). Two groups of patients in the psychological function, body image, sexual function was statistically significant (P <0.05). Conclusion The long-term clinical effects of breast-conserving surgery and breast reconstruction in patients with breast cancer have no significant difference, but have some impact on some patients’ quality of life psychological function, body image and sexual function.