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目的观察重组人白细胞介素-11(rhIL-11)、达那唑、泼尼松联合治疗中老年特发性血小板减少性紫癜的临床疗效。方法研究对象为我科住院60例中老年特发性血小板减少性紫癜的患者,随机分成治疗组(应用rhIL-11达那唑、泼尼松联合治疗)和对照组(单纯用泼尼松)。治疗组应用rhIL-1125ug/(kg·d)皮下注射、达那唑0·2g2次/d、泼尼松0·5mg/(kg·d)联合治疗,至血小板正常后,给予达那唑0·2g2次/d、泼尼松0·5mg/(kg·d)联合维持治疗;对照组单用泼尼松1mg/(kg·d)治疗,治疗过程中在血小板恢复正常之前每天或隔天复查血常规,每周复查肝肾功能、心电图、凝血分析。结果治疗组在血小板开始上升时间、血小板达峰值时间、控制出血症状时间均少于单用泼尼松组(P<0·01),治疗组总有效率90%,高于单用泼尼松组的65%(P<0·05)。结论rhIL-11联合达那唑及肾上腺皮质激素治疗可以有效促进ITP患者外周血小板的恢复,迅速控制ITP患者的出血症状。
Objective To observe the clinical efficacy of recombinant human interleukin-11 (rhIL-11), danazol, and prednisone in the treatment of idiopathic thrombocytopenic purpura in middle-aged and elderly patients. Methods The subjects were 60 patients with idiopathic idiopathic idiopathic thrombocytopenic purpura in our department. They were randomly divided into treatment group (rhIL-11 danazol and prednisone combination) and control group (prednisone alone) . The treatment group was given rhIL-1125ug / (kg · d) subcutaneous injection of danazol 0 · 2g2 times / d, prednisone 0.5mg / (kg · d) combined treatment to platelets after normal administration of danazol 0 · 2g 2 times / d, prednisone 0 · 5mg / (kg · d) combined with maintenance therapy; control group treated with prednisone 1mg / (kg · d) only, during the treatment before platelet recovery normal every day or every other day Review of blood routine, weekly review of liver and kidney function, electrocardiogram, coagulation analysis. Results In the treatment group, the time when the platelets started to rise, the peak time of the platelets and the bleeding time were all less than those in the prednisone-only group (P <0.01). The total effective rate was 90% in the treatment group, which was higher than that in the prednisone- Group 65% (P <0.05). Conclusion rhIL-11 combined with danazol and adrenocorticotropic hormone therapy can effectively promote the recovery of peripheral platelets in patients with ITP, rapid control of bleeding symptoms in patients with ITP.