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癫痫是神经系统常见疾病之一,其患病率约为0.5％,而女性患者中的50～70％的癫痫发作只在月经期或是在月经期发作次数增加,这即所谓的经期性癫痫。自1885年Gowers首次提出“癫痫发作在月经期加重”以来,不少学者认为很可能经期性癫痫与女性激素的周期性变化有关,即提出了癫痫发作中雌激素的致痫性和孕激素的抗痫作用。我们选用放免法测定女性癫痫患者月经期血清中雌二醇、孕酮之浓度,并对经期性癫痫患者、非经期性癫痫患者及正常人进行对比,以期了解经期性癫痫的可能原因。
Epilepsy is one of the most common neurological diseases with a prevalence of about 0.5%, whereas seizures in women of 50% to 70% increase only during menstruation or during menstruation, which is called epileptic seizures . Since Gowers first proposed in 1885, “Epileptic seizures increase in the menstrual period,” many scholars think it is likely that epilepsy and cyclical changes in women’s hormones, that is proposed epileptic seizures estrogen and progesterone Anti-epileptic effect. We use radioimmunoassay to determine the serum estradiol and progesterone concentrations in women with epilepsy and compare the patients with epilepsy, non-epileptic patients and normal subjects in order to understand the possible causes of epilepsy.