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目的探讨Castleman病的临床表现及外科治疗。方法对我院自2003年6月起收治的8例Castleman病患者的临床资料进行分析。结果Castleman病临床分为局灶型(LCD)和多中心型(MCD),LCD多表现为单发淋巴结肿大并周围卫星病灶,而MCD表现为全身多处淋巴结肿大。LCD7例行手术切除,MCD1例行手术活检,所有病例均经病理明确诊断。LCD手术切除疗效好。结论手术切除是LCD的主要治疗手段,仔细分离、结扎血管及剔除淋巴滤泡是手术的关键。而对于MCD,手术活检有助于明确诊断及指导进一步治疗。
Objective To investigate the clinical manifestations and surgical treatment of Castleman’s disease. Methods The clinical data of 8 patients with Castleman’s disease admitted to our hospital from June 2003 were analyzed. Results Castleman’s disease was divided into focal (LCD) and multicentric (MCD). The LCD showed single lymph node enlargement and peripheral satellite lesions, while MCD showed multiple systemic lymph nodes. LCD7 routine surgical resection, MCD1 routine biopsy, all cases were diagnosed by pathology. LCD surgery is effective. Conclusions Surgical resection is the main treatment of LCD. Careful separation, ligation of blood vessels and elimination of lymphoid follicles are the key to surgery. For MCD, surgical biopsy can help confirm the diagnosis and guide further treatment.