论文部分内容阅读
目的探讨冠心病合并抑郁与内皮型一氧化氮合酶基因G894T位点多态性的关系。方法冠心病患者217例,分为冠心病合并抑郁组39例和冠心病组178例,选择同期抑郁症患者45例(抑郁症组)与健康体检者85名(对照组)。检测4组内皮型一氧化氮合酶基因G894T位点多态性,并分析4组间差异。结果 4组内皮型一氧化氮合酶基因G894T位点GT杂合基因型和T等位基因频率分布两两比较差异均无统计学意义(P>0.05)。结论冠心病合并抑郁与一氧化氮合酶基因G894T位点多态性无明显相关性。
Objective To investigate the relationship between coronary heart disease with depression and endothelial nitric oxide synthase gene G894T polymorphism. Methods A total of 217 patients with coronary heart disease were divided into coronary heart disease with depression group (39 cases) and coronary heart disease group (with coronary heart disease group). 45 cases of depression (depression group) and 85 healthy subjects (control group) were selected. Four groups of endothelial nitric oxide synthase gene G894T polymorphism were detected and the differences between the four groups were analyzed. Results There was no significant difference in frequency distribution of GT heterozygous genotype and T allele in G894T locus between the four groups (P> 0.05). Conclusion There is no significant correlation between coronary heart disease complicated with depression and polymorphism of nitric oxide synthase gene G894T.