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目的 探讨子宫内膜异位症的严重程度对体外受精 胚胎移植 (IVF ET)各个环节的影响。方法 对1999年 1月至 2 0 0 2年 4月在中山大学附属第一医院 10 7例已明确分期的子宫内膜异位症不育患者共 139周期IVF ET与同期输卵管因素不育患者 139例进行的 139周期IVF ET的控制性超排卵 (COH)治疗、受精率、卵裂率、每周期胚胎植入率和临床妊娠率、流产率等进行回顾性对照分析。结果 中、重度子宫内膜异位症不育患者与对照组相比进行IVF治疗时使用促性腺激素的总量增加而获卵数减少。重度患者雌二醇 (E2 )峰值下降 ,流产率增加 ,差异有统计学意义 (P <0 0 5 )。子宫内膜异位症不育患者IVF ET治疗时随着病情加重 ,卵巢对控制性超排卵的反应性下降 ,重度患者流产率增高。结论 子宫内膜异位症影响了卵子与胚胎的发育。
Objective To investigate the severity of endometriosis in vitro fertilization embryo transfer (IVF ET) in all aspects of the impact. Methods From January 1999 to April 2002 in the First Affiliated Hospital of Sun Yat - sen University, 107 cases of patients with endometriosis have been clearly staged a total of 139 cycles of IVF ET with the same fallopian tube infertility 139 Cases of controlled IVF ET of 139 cycles of controlled ovarian hyperstimulation (COH) treatment, fertilization rate, cleavage rate, weekly embryo implantation rate and clinical pregnancy rate, abortion rate were retrospectively controlled analysis. As a result, patients with severe endometriosis infertility had fewer oocytes by using the total amount of gonadotropins when they were treated with IVF compared with the control group. Severe patients with estradiol (E2) peak decreased abortion rate increased, the difference was statistically significant (P <0 05). With infertility patients with endometriosis IVF ET treatment as the disease progresses, ovarian response to controlled superovulation decreased, severe cases of miscarriage increased. Conclusion Endometriosis affects the development of ovum and embryo.