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目的:研究肝硬化患者肝纤维化标志物与Child-Pugh分级的关系。方法:检测70例肝硬化患者血清透明质酸(HA)、Ⅲ型前胶原(HPCⅢ)、Ⅳ型胶原(Ⅳ-C)及层粘连蛋白(LN)。结果:肝硬化患者肝纤维化指标血清HA、PCⅢ、IVC、LN测定结果均显著高于对照组(P<0.01),并且随着肝硬化Child-Pugh分级的增加而增高,同一标志物各分级之间的结果存在显著性差别(P<0.05)。结论:肝纤维化指标随肝硬化Child-Pugh分级的递增而递增,肝纤维化标志物对判断肝硬化患者病情及预后具有重要的临床意义。
Objective: To study the relationship between liver fibrosis markers and Child-Pugh classification in patients with cirrhosis. Methods: Serum hyaluronic acid (HA), type Ⅲ procollagen (HPC Ⅲ), type Ⅳ collagen (Ⅳ-C) and laminin (LN) were detected in 70 patients with cirrhosis. Results: The serum levels of HA, PCⅢ, IVC and LN in liver cirrhosis patients were significantly higher than those in the control group (P <0.01), and increased with the increase of Child-Pugh cirrhosis grade. The same markers were graded There was a significant difference between the results (P <0.05). Conclusion: The index of liver fibrosis increases with the increase of Child-Pugh classification of liver cirrhosis. Liver fibrosis markers have important clinical significance in judging the condition and prognosis of patients with cirrhosis.