目前认为,肿瘤的发生发展除了与细胞增殖失控和细胞分化异常有关外,另一个重要原因是发生转化的细胞不能正常凋亡,而细胞凋亡(又称程序性死亡)是基因编程调控的细胞自主性死亡过程。已知多种因素参与诱导和抑制细胞凋亡,而细胞表面的受体和配体相互作用在诱导凋亡中起主导作用 At present, it is thought that in addition to the uncontrolled cell proliferation and the abnormal cell differentiation, another important reason for the occurrence and development of tumors is that the transformed cells can not normally apoptosis, and apoptosis (also referred to as programmed death) is a gene programmed regulation of cells Autonomous death process. A variety of factors are known to be involved in the induction and inhibition of apoptosis and the receptor-ligand interaction on the cell surface plays a dominant role in the induction of apoptosis