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目的分析HLA-DRB1等位基因型别与个体乙肝疫苗免疫应答水平的相关性。方法对37名湖北汉族健康自愿者进行HBV血源型疫苗标准全程接种,共3次(0,1,6月),末次接种后8周用酶免疫法(EIA)检测血清抗-HBs抗体水平(S/N≥2.1为应答者,S/N<2.1为无应答者);同时,对全部受试者进行HLA-DRB1基因分型。结果37名个体中无应答者7名(19%),应答者30名(81%),无应答与HLA-DRB*1001等位基因具有显著相关性,RR=21.75,X2=5.55,P<0.05。结论在湖北汉族人群中,携带HLA-DRB*1001等位基因个体对乙肝疫苗的免疫应答水平明显低于其他个体
Objective To analyze the correlation between the HLA-DRB1 allele and the level of individual hepatitis B vaccine immune response. Methods Thirty-seven healthy volunteers from Han nationality of Hubei Province were vaccinated with HBV blood-borne vaccine for three times in total (0, 1, 6 months). Serum anti-HBs antibody levels were measured by enzyme-linked immunosorbent assay (EIA) (S / N≥2.1 for responders, S / N <2.1 for non-responders); at the same time, all subjects were HLA-DRB1 genotyping. RESULTS: There were 7 (19%) of 37 individuals without response and 30 (81%) of responders with no significant association with HLA-DRB * 1001 allele (RR = 21.75, X2 = 5.55, P < 0.05. Conclusion The HLA-DRB * 1001 allele in Hubei Han population showed significantly lower immune response to hepatitis B vaccine than other individuals