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目的:观察不同抗组胺药是否具有抗炎作用。方法:给大鼠鼠爪皮下注射花生四烯酸(1.0 g/L,0.1 mL)构建鼠爪水肿炎性模型,在注射花生四烯酸2 h前分别灌胃给予咪唑斯汀、地氯雷他定、依巴斯汀3种抗组胺药(0.3 mg/kg),注射后1、2、3、4h,应用体积测量仪分别测定给药后鼠爪体积的改变。结果:咪唑斯汀(0.3 mg/kg)显著抑制花生四烯酸诱导的鼠爪水肿(P<0.05),地氯雷他定、依巴斯汀对花生四烯酸诱导的鼠爪水肿均无抑制作用(P>0.05)。结论:0.3 mg／kg的咪唑斯汀在体内具有抗炎作用,相同剂量的地氯雷他定、依巴斯汀无抗炎作用。
Objective: To observe whether different antihistamines have anti-inflammatory effects. METHODS: Rat paw edema was induced by subcutaneous injection of arachidonic acid (1.0 g / L, 0.1 mL) into rat paw edema model. Mogadustine and desloratadine He determined, according to Bastin 3 antihistamines (0.3 mg / kg), 1,2,3,4 h after injection, the volume of the measuring instrument were measured after administration of rat paw volume changes. Results: Mizolastine (0.3 mg / kg) significantly inhibited arachidonic acid induced rat paw edema (P <0.05), desloratadine and ebastine on arachidonic acid induced rat paw edema Inhibition (P> 0.05). CONCLUSION: Mizolastine 0.3 mg / kg has an anti-inflammatory effect in vivo. The same dose of desloratadine and ebastine has no anti-inflammatory effect.