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根据近年来慢性乙型肝炎抗病毒治疗的研究进展和临床诊治实际需求，中华医学会肝病学分会特制订此专家意见，建议在人群中扩大HBsAg筛查并采用高灵敏HBV DNA检测方法，降低启动慢性乙型肝炎患者治疗的丙氨酸转氨酶阈值，积极治疗有疾病进展风险和“不确定期”患者，在经治低病毒血症患者中换用、加用或联用抗病毒药物。“,”To meet the unmet medical needs and better reflect the new clinical evidence of chronic hepatitis B management, Chinese Society of Hepatology developed expert consensus on expanding diagnosis and treatment in China. The recommendations include to expand HBsAg screening in the population and HBV DNA detection by sensitive quantitative real-time PCR (qPCR), decrease the alanine aminotransferase (ALT) threshold for treatment of chronic hepatitis B, and promptly start antiviral therapy in the patients who are at risk of disease progression, and appropriately manage the patients with low level viremia.