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作者通过荷兰猪的实验,对青春期引起第一次排卵的动因进行探讨。在哺乳类引起第一次排卵的真正动因尚不清楚。多认为在青春期成熟前,通过卵巢的甾类激素对促性腺激素的负反馈调节来控制。通过观察女性接近第一次排卵期雌激素对促性腺激素分泌的抑制作用减弱。但是抑制 LH 分泌的改变是由于下丘脑对负反馈的敏感性降低抑或是由于持续分泌散放 LH 的成熟改变尚不清楚,但与卵巢甾类激素的负反馈无关。因此探讨 LH 持续分泌的浓度和猪激素对于 LH 释放的负反馈作用很重要。作者对四组不同年龄组(分别为10、30、50和150天)的荷兰猪行双侧卵巢切除术、注射雌激素及促性腺激素释放激素(LHRH)。然后观察其血清LH 浓度改变情况。实验结果发现在年龄较大的三组动物中,切除卵巢后均可引起 LH 高峰。最高可达1,200～1,400
Through the experiment of Dutch pig, the author discusses the motivation of the first ovulation during adolescence. The true cause of first ovulation in mammals is unclear. Many believe that before adolescence maturation, ovarian steroid hormones on the negative feedback regulation of gonadotropin to control. By observing the female close to the first ovulation estrogen on the secretion of gonadotropin inhibition weakened. However, it is unclear whether the change in inhibition of LH secretion is due to the decreased sensitivity of the hypothalamus to negative feedback or the maturation of LH due to sustained secretion, but not to negative feedback from ovary steroid hormones. Therefore, it is important to explore the sustained secretion of LH and the negative feedback of LH on LH. The authors double-sided oophorectomy, injection of estrogen and gonadotropin-releasing hormone (LHRH) in four Dutch pigs of different age groups (10, 30, 50 and 150 days, respectively) Then observe the change of serum LH concentration. The experimental results found that in the older three groups of animals, ovaries can cause LH peak. Up to 1,200 ~ 1,400