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目的:了解survivin基因的表达在小儿急性白血病发病过程中的意义。方法:用RT-PCR测定小儿急性白血病初诊患者survivin基因的表达,并结合临床特征、初步治疗反应进行比较。共研究了54例小儿白血病患儿并以36例非恶性血液病为对照,根据survivin基因的阳性和阴性分为2组,分析其临床特征和早期的治疗反应。结果:Survivin基因在非恶性血液病组中无1例被检出,白血病组中共41例被测出,明显高于对照组(P<0.001)。survivin基因阳性组的早期治疗反应好的病例数明显低于阴性病例组(P<0.01)。结论:测定survivin基因对诊断、判断预后、残留白血病的检测意义较大。
Objective: To understand the significance of survivin gene expression in the pathogenesis of childhood acute leukemia. Methods: The expression of survivin gene in newly diagnosed pediatric acute leukemia patients was determined by RT-PCR, and the clinical response was compared with the clinical features. A total of 54 children with childhood leukemia were studied and 36 cases of non-hematologic malignancies were used as control. The survivin gene was divided into two groups based on the positive and negative results. The clinical features and early treatment response were analyzed. Results: None of Survivin gene was detected in non-hematologic malignancies, 41 cases in leukemia group were detected, which were significantly higher than those in control group (P <0.001). Survivin gene positive group early treatment response was significantly lower than the number of negative cases (P <0.01). Conclusion: The detection of survivin gene has great significance in diagnosis, prognosis and residual leukemia.