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抗凝血药物肝素钠中国药典一九七七年版和美国药典第20版中质量标准均没有要求检查钾限量,但是我国出口的肝素钠除规定按美国药典20版标准规格检验外,并要求其中钾限量不得超过1％。根据工艺流程在精制工段如用高锰酸钾氧化法最终在精制品中可能夹杂钾离子,而应用含钾过高的肝素钠注射后会引起肌肉疼痛,血钾过高而对心肌产生抑制作用,同时并可影响体内细胞内外之间的平衡,渗透压
Anticoagulant drugs Heparin sodium Chinese Pharmacopoeia 1977 edition and the United States Pharmacopoeia 20 edition of the quality standards are not required to check the potassium limit, but China’s exports of heparin in addition to the provisions of the United States Pharmacopoeia 20 version of the standard test, and require Potassium limit of not more than 1%. According to the process in the refining process, such as potassium permanganate oxidation eventually refined products may be mixed with potassium ions, and the application of potassium over high heparin sodium injection can cause muscle pain, hyperkalemia and myocardial inhibition , At the same time and can affect the balance between the cells inside and outside the body, osmotic pressure