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目的:观察达英-35(Diane-35)联合克罗米芬(CC)治疗多囊卵巢综合征(Polycystic Ovarv Syndrome,P-COS)所致不孕症的疗效。方法:诊断明确的多囊卵巢综合征性不孕的36例患者服用达英-35 3个周期,观察治疗前后患者性激素(LH、FSH、T、E2)的变化,治疗前后子宫体积、子宫内膜厚度、卵巢体积、卵泡个数。达英-35治疗满3个周期后,36例患者随机分为促排卵(达英-35+CC)组24例和未促排卵组12例。结果:36例患者治疗前后性激素比较,LH、LH/FSH、T都显著降低,差异有统计学意义(P<0.05)。SHBG治疗后较治疗前明显升高,差异有统计学意义(P<0.05)。促排卵组周期排卵率82.86%,妊娠率达25%,未排卵组周期排卵率58.33%,妊娠率16.67%,两组疗效比较,差异有统计学意义(P<0.05)。结论:达英-35联合CC治疗PCOS所致不孕症能获得较高的排卵率及受孕率。
Objective: To observe the efficacy of Diane-35 combined with clomiphene citrate in the treatment of infertility caused by polycystic ovarian syndrome (P-COS). Methods: Thirty-six patients with definite polycystic ovary syndrome infertility were enrolled in the study. The changes of sex hormones (LH, FSH, T, E2) before and after treatment were observed. The changes of uterine volume, intrauterine Film thickness, ovarian volume, the number of follicles. After up to 3 weeks of treatment, 36 patients were randomly divided into 24 cases of ovulation induction (up to -35 + CC) group and 12 cases of non-ovulation induction group. Results: The levels of LH, LH / FSH and T in 36 patients before and after treatment were significantly lower than those before treatment (P <0.05). SHBG treatment than before treatment was significantly higher, the difference was statistically significant (P <0.05). Ovulation ovulation rate was 82.86%, pregnancy rate was 25%, ovulation rate was 58.33%, pregnancy rate was 16.67%, the difference between the two groups was statistically significant (P <0.05). CONCLUSION: Da-Ying-35 combined with CC treatment of infertility caused by PCOS can get a higher ovulation rate and pregnancy rate.