已有报告说,当婴幼儿食入或吸入雌激素,于乳房部位局部使用雌激素,以及为了治疗尿布疹而局部使用含雌激素的药品,或为了治疗头皮疾患而用含雌激素的药品涂于头皮上后发生了性早熟。最近,美国得克萨斯州布鲁克陆军医学中心等又在《美国临床儿科学》杂志上报告了4例1岁～7岁女孩,在 It has been reported that topical use of estrogen in infants and young children when estrogen is ingested or inhaled, topical use of estrogen in the breast area, topical use of estrogen-containing drugs for the treatment of diaper rash, or topical application of estrogen-containing drugs to treat scalp disorders After the scalp on the occurrence of sexual precocity. Recently, Brookhaven Medical Center in Brookhaven, Texas, USA, again reported in the American Journal of Clinical Pediatrics four girls aged 1 to 7 years old