白念珠菌是临床最常见的条件致病真菌,可以导致黏膜和系统感染。临床上广泛使用的抗真菌药物数量有限,长期广泛应用于临床所导致白念珠菌的耐药现象越来越普遍,耐药程度也越来越高。白念珠菌对抗真菌药物的高适应性导致了耐药性的产生,同时也是白念珠菌对环境应激的一种体现。本文对应激反应通路作了总结,并着重从应激反应角度阐述了白念珠菌的耐药性问题。 Candida albicans is the most common condition in clinical pathogenic fungi, can lead to mucosal and systemic infections. The clinical use of antifungal drugs is widely used in a limited number of long-term clinical application of Candida albicans resistance is becoming more common, more and more resistant. Candida albicans against the high adaptability of fungal drugs led to the emergence of drug resistance, but also an indicator of Candida albicans on environmental stress. This article summarizes the pathways of stress response and focuses on the resistance of Candida albicans from the perspective of stress response.