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目的探讨维吾尔族和汉族老年收缩性心力衰竭患者N端脑钠肽前体(NT-proBNP)水平与心功能分级、左室射血分数(LVEF)、左心室舒张末期内径(LVEDD)的差异,为构建防治HF的综合策略提供有效依据。方法选择符合诊断标准的维吾尔族和汉族老年(年龄≥60岁)收缩性心力衰竭住院患者共214例,患者入院24 h内完善NT-proBNP、LVEF和LVEDD检查,分析NTproBNP与心功能分级、LVEF和LVEDD的水平变化及差异。结果 2组患者NT-proBNP水平均随着心功能分级、LVEDD的递增而逐级升高,各心功能级别间比较具有明显统计学意义(P<0.05);2组患者NT-proBNP水平均随着LVEF值的下降而增加,各组之间比较具有统计学意义(P<0.05)。结论维吾尔族和汉族老年收缩性心力衰竭患者血浆NT-proBNP水平存在差异,心功能越差,差异越显著。
Objective To investigate the differences of NT-proBNP level, heart function classification, left ventricular ejection fraction (LVEF) and left ventricular end-diastolic dimension (LVEDD) in elderly patients with systolic heart failure in Uygur and Han nationality. Provide a valid basis for building a comprehensive strategy to prevent and treat HF. Methods A total of 214 hospitalized patients with systolic heart failure were enrolled in this study. NT-proBNP, LVEF and LVEDD were examined within 24 h after admission. The correlation between NTproBNP and cardiac function classification, LVEF And LVEDD level changes and differences. Results NT-proBNP levels in both groups increased gradually with the increase of cardiac function grade and LVEDD, and the levels of NT-proBNP in each group were significantly different (P <0.05). The NT-proBNP levels LVEF value decreased and increased, the comparison between the groups was statistically significant (P <0.05). Conclusion The plasma levels of NT-proBNP in elderly patients with systolic heart failure in Uygur and Han are different. The worse the heart function, the more significant difference.