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将肿瘤靶向基团5-(4-氨基苯基)-10,15,20-三(4-磺酸苯基)卟啉钠(APTSPP)与二乙三胺五乙酸(DTPA)分别键接在葡聚糖侧链上,再与钆Gd(III)离子配合,从而研制出一种新型含卟啉基葡聚糖大分子磁共振成像造影剂(APTSPP-Dextran-DTPA-Gd).对所合成的配体及钆配合物分别进行了核磁共振氢谱、紫外可见光谱、傅里叶变换红外光谱等结构表征,分析了钆配合物在水溶液中的粒径分布和Zeta电位,测试了钆配合物的体外弛豫率与新西兰大白兔体内肿瘤磁共振成像性能.与Gd-DTPA相比,所得钆配合物具有较高的弛豫率,对VX2肿瘤有良好的磁共振成像性能与靶向性,能对磁共振成像的对比度与清晰度有较好的提高.
The tumor target group sodium 5- (4-aminophenyl) -10,15,20-tris (4-sulfophenyl) porphyrin (APTSPP) and diethylenetriamine pentaacetic acid (DTPA) In the dextran side chain, and then with gadolinium Gd (III) ion coordination, thus developed a new porphyrin-containing dextran macromolecular magnetic resonance imaging contrast agent (APTSPP-Dextran-DTPA-Gd) The synthesized ligands and gadolinium complexes were characterized by 1H-NMR, UV-Vis and Fourier transform infrared spectroscopy, respectively. The particle size distribution and Zeta potential of gadolinium complex in aqueous solution were analyzed. Compared with Gd-DTPA, the obtained gadolinium complex has higher relaxation rate, good magnetic resonance imaging performance and good targeting to VX2 tumors , Can improve the contrast and clarity of magnetic resonance imaging.