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目的:测定子宫肌瘤、卵巢囊肿患者血清及病理组织中酞酸酯类化学物(PAEs)水平并分析其相关性。方法:收集80例子宫肌瘤和67例卵巢囊肿患者的手术病理组织和血液样本,采用气相色谱法(GC)测定PAEs含量。并对病理组织与血清中邻苯二甲酸二丁酯(DBP)和邻苯二甲酸二(2-乙基-己基)酯(DEHP)水平进行相关性分析。结果:患者病理组织中DEP、DBP和DEHP的检出率分别为0、74.8%和99.3%。卵巢囊肿病理组织中DBP和DEHP水平分别为0.457μg/g和4.123μg/g,均显著高于子宫肌瘤组织(0.202μg/g、2.317μg/g,P<0.001)。子宫肌瘤患者血清中DEHP与病理组织中DBP和DEHP的水平均呈负相关(r=-0.241,P<0.05;r=-0.309,P<0.01);卵巢囊肿患者血清中DBP与病理组织中DBP含量呈负相关(r=-0.255,P<0.05);卵巢囊肿患者的黄体生成素水平显著低于子宫肌瘤患者(3.80IU/L vs 8.72IU/L,P<0.05)。结论:PAEs对女性人群暴露与子宫肌瘤、卵巢囊肿发病的相关性研究有一定的参考意义。
Objective: To determine the levels of phthalate esters (PAEs) in the serum and pathological tissues of patients with uterine fibroids and ovarian cysts and analyze their correlation. Methods: The pathological tissues and blood samples of 80 patients with uterine fibroids and 67 patients with ovarian cysts were collected. The content of PAEs was determined by gas chromatography (GC). The correlations between pathological tissues and serum dibutyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) were also analyzed. Results: The detection rates of DEP, DBP and DEHP in pathological tissues were 0, 74.8% and 99.3% respectively. The levels of DBP and DEHP in pathological tissues of ovarian cysts were 0.457μg / g and 4.123μg / g, respectively, which were significantly higher than that of uterine fibroids (0.202μg / g, 2.317μg / g, P <0.001). The serum levels of DEHP in patients with uterine fibroids were negatively correlated with the levels of DBP and DEHP in pathological tissues (r = -0.241, P <0.05; r = -0.309, P <0.01) (R = -0.255, P <0.05). The level of luteinizing hormone in patients with ovarian cysts was significantly lower than that in patients with uterine fibroids (3.80 IU / L vs 8.72 IU / L, P <0.05). Conclusion: PAEs have some reference significance for the study of the correlation between female population exposure and the incidence of uterine fibroids and ovarian cysts.