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为探讨矽肺与一氧化氮和抗氧化剂的关系， 我们检测了７３ 例矽肺患者和６０ 例健康对照者血浆中的一氧化氮（Ｐ－ ＮＯ） 、维生素Ｃ （Ｐ－ ＶＣ） 、维生素Ｅ（Ｐ－ ＶＥ） 、β－ 胡萝卜素（Ｐ－ β－ ＣＡＲ） 浓度。结果表明， 与对照组比较， 患者组的Ｐ－ ＮＯ 平均浓度显著升高， Ｐ－ ＶＣ、Ｐ－ ＶＥ、Ｐ－ β－ ＣＡＲ 平均浓度均显著降低（ Ｐ＜ ０－００１） ； 各检测值与患者病程、病情、肺功能状态均有相关； 逐步回归表明， 患者病程、病情、肺功能状态与Ｐ－ ＮＯ、Ｐ－ ＶＥ 相关最密切。提示矽肺患者一氧化氮代谢异常， 氧化抗氧化平衡严重失调。
To investigate the relationship between silicosis and nitric oxide and antioxidants, we examined the levels of plasma nitric oxide (P-NO), vitamin C (P-VC) and vitamin E (P) in 73 patients with silicosis and 60 healthy controls - VE), beta-carotene (P-beta-CAR) concentrations. The results showed that compared with the control group, the average concentration of P-NO in patients increased significantly, while the average concentrations of P-VC, P-VE and P-CAR significantly decreased (P <0-001) Patient’s course, condition and pulmonary function status were correlated. Stepwise regression showed that patient’s course, condition and pulmonary function were most closely related to P-NO and P-VE. Prompt nitric oxide metabolism in patients with silicosis, a serious imbalance of oxidation and anti-oxidation.