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目的通过分析天津市滨海新区塘沽2005—2014年疑似预防接种异常反应(adverse events following immunization,AEFI)的发生特征,评价预防接种的安全性及AEFI信息管理系统的敏感性。方法通过搜集既往档案资料及AEFI信息管理系统,收集截至2014年9月30日报告的AEFI个案数据,用描述流行病学方法进行统计。结果滨海新区塘沽共报告AEFI 440例,报告发生率为22.17/10万;其中一般反应379例(86.14%),异常反应57例(12.95%),偶合症3例(0.68%),心因性反应1例(0.23%),无疫苗质量和接种事故。23价和7价肺炎疫苗发生率(115.47/10万和91.41/10万)高于其他疫苗。结论滨海新区塘沽AEFI监测水平不断提高,今后要继续加强基层人员的培训,在规范接种的基础上,不断提高AEFI监测、调查诊断、处置水平。
Objective To evaluate the safety of vaccination and the sensitivity of AEFI by analyzing the occurrence of suspected AEFI in Tanggu, Binhai, Tianjin from 2005 to 2014. Methods Collecting data on AEFI cases reported as of September 30, 2014, by collecting historical archives and AEFI information management systems, were used to describe epidemiological statistics. Results A total of 440 AEFI cases were reported in Tanggu District of Binhai New Area, with a reported incidence of 22.17 / 100 000; 379 (86.14%) were general reactions, 57 (12.95%) were anomalous reactions, 3 (0.68% Response in 1 case (0.23%), no vaccine quality and vaccination accident. The incidence of 23- and 7-valent pneumococcal vaccines (115.47 / 100,000 and 91.41 / 100,000) was higher than for other vaccines. Conclusion The monitoring level of AEFI in Tanggu District of Binhai New Area continues to increase. In the future, it is necessary to continue to strengthen the training of grassroots personnel. On the basis of standardized vaccination, the AEFI monitoring, investigation and diagnosis and treatment levels should be continuously improved.