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目的观察5-氨基酮戊酸光动力疗法、手术及咪喹莫特联合治疗皮肤基底细胞癌的效果。方法将92例皮肤基底细胞癌患者随机分为研究组与对照组,每组46例。对照组患者采用单纯5-氨基酮戊酸光动力疗法治疗,研究组患者在对照组治疗的基础上联合手术和外用咪喹莫特等治疗。对比2组临床疗效和5-氨基酮戊酸光动力治疗次数。结果所有患者随访6个月,研究组患者治疗总有效率明显高于对照组,复发率明显低于对照组,5-氨基酮戊酸光动力疗法治疗次数明显低于对照组,差异均有统计学意义(P<0.05)。结论 5-氨基酮戊酸光动力疗法、手术及咪喹莫特联合应用治疗皮肤基底细胞癌能够有效提高治疗有效率,而且能够有效预防患者再次复发,同时能够减少5-氨基酮戊酸光动力疗法治疗次数,有效舒缓患者心理压力,值得在临床推广应用。
Objective To observe the effect of 5-aminolevulinic acid photodynamic therapy, surgery and imiquimod in the treatment of cutaneous basal cell carcinoma. Methods 92 patients with cutaneous basal cell carcinoma were randomly divided into study group and control group, with 46 cases in each group. Patients in the control group were treated with 5-aminolevulinic acid photodynamic therapy alone. Patients in the study group were treated with the combination of surgery and topical imiquimod on the basis of the control group. The clinical efficacy and the number of photodynamic therapy of 5-aminolevulinic acid were compared between the two groups. Results All patients were followed up for 6 months. The total effective rate of study group was significantly higher than that of control group, and the recurrence rate was significantly lower than that of control group. The number of 5-aminolevulinic acid photodynamic therapy was significantly lower than that of control group Significance (P <0.05). Conclusions Combination of 5-aminolevulinic acid photodynamic therapy, operation and imiquimod in the treatment of basal cell carcinoma of the skin can effectively improve the therapeutic efficiency, and can effectively prevent the recurrence of patients and reduce the photodynamic activity of 5-aminolevulinic acid Therapeutic treatment times, effective relief of patients with psychological stress, it is worth in the clinical application.