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目的研究分析紫杉醇铂剂化疗方案治疗Ⅲ、Ⅳa鼻咽癌的临床治疗效果及不良反应。方法选取我院于2012年7月至2013年5月收治的76例Ⅲ、Ⅳa鼻咽癌患者,将其均分为两组,对照组接受5-氟尿嘧啶+顺铂同期放疗方法实施治疗,治疗组患者接受紫杉醇+顺铂+5-氟尿嘧啶辅助同期放疗方法实施治疗,对比两组患者的临床治疗效果以及不良反应。结果治疗组患者的鼻咽、颈部、鼻咽颈部治疗效果显著优于对照组,对比有统计学意义(P<0.05),两组患者1年、2年生存率以及不良反应对比均无明显差异,对比无统计学意义(P>0.05)。结论采用紫杉醇铂剂化疗方案治疗Ⅲ、Ⅳa鼻咽癌,可有效治疗患者的肿瘤病症,临床治疗效果显著,值得在临床医学中推广使用。
Objective To study the clinical effects and adverse reactions of paclitaxel platinum chemotherapy in the treatment of stage Ⅲ and Ⅳa nasopharyngeal carcinoma. Methods Totally 76 patients with stage Ⅲ and Ⅳa nasopharyngeal carcinoma admitted from July 2012 to May 2013 in our hospital were divided into two groups. The control group received concurrent 5-fluorouracil plus cisplatin concurrent radiotherapy and treatment Group received paclitaxel + cisplatin + 5-fluorouracil concurrent treatment of radiation therapy, the two groups of patients compared the clinical effect and adverse reactions. Results The therapeutic effects of the nasopharyngeal, cervical and nasopharyngeal neck in the treatment group were significantly better than those in the control group (P <0.05). The 1-year, 2-year survival rates and the adverse reactions of the two groups were not significantly different Significant differences, the comparison was not statistically significant (P> 0.05). Conclusion Paclitaxel platinum chemotherapy regimen for the treatment of Ⅲ, Ⅳa nasopharyngeal carcinoma, which can effectively treat patients with tumor disorders, the clinical treatment of significant effect, it is worth to promote the use of clinical medicine.